This conversation explores how chronic stress affects the brain, particularly the prefrontal cortex and its role in decision-making.

Dr. Amy Arnsten explains how stress can impair cognitive function, why founders may be especially vulnerable and what the science says about recovery.

She also discusses the importance of feeling in control, how stress can shift us toward more reactive behavior and what habits may help protect cognitive performance.

In this conversation, Dr. Michael A. Freeman discusses the unique vulnerabilities faced by entrepreneurs, highlighting the mental health challenges they encounter and the systemic issues that contribute to their well-being.

He emphasizes the need for a public health approach to address these challenges, the impact of founder well-being on broader economic systems and the role of investors in supporting mental health initiatives.

The discussion also touches on the connection between mental and physical health, the neurodiversity of entrepreneurs and the importance of community alongside support systems.

In this conversation, Dr. Bill Becker explores the effects of an always-on work environment and the pressure to remain constantly available.

He explains how expectations around email and after-hours communication can increase anxiety, disrupt sleep and strain relationships at home and on the job.

Dr. Becker also examines how leaders shape the norms around them and practical ways to create healthier boundaries while managing the demands of building a company.